News from PCOS Research – improved conditions
News in PCOS research: role of theca cell and androgen production, stem cell therapy, metabolic syndrome in PCOS and interesting improved conditions!
News: Excess androgen production by theca cells may be key
El Andaloussi et al. stated following in their published study «Human mesenchymal stem cells secretome (hMSCs) inhibits androgen production by human theca-like cells: implications for stem cell therapy of polycystic ovarian syndrome”, in Reproductive Sciences, 26 : 282A-283A, (2019) that PCOS etiology is not fully understood. Excess ovarian androgen production by theca cells is thought to be a central factor in driving this pathology. And they showed in their cell based laboratory study an experimental work on human theca cells established from PCOS patients.
Stem Cell therapy a new approach? They concluded that therapeutic hMSCs capabilities in PCOS are mediated, at least in part, by their ability to inhibit androgen biosynthesis by theca cells. Stem cell therapy might potentially be a novel approach for effective treatment of PCOS-related morbidities.
News: Higher Risk for Metabolic Syndrome (MetS) in Women with PCOS
Conclusion of the article “The association between metabolic syndrome and polycystic ovary syndrome: A systematic review and meta-analysis” published in Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 13.2 : 1481-1489, (2019) by Otaghi, Masoumeh et al. was that according to the results, there is higher risk of MetS in women with PCOS.
Therefore, diagnosis and treatment of MetS in women with PCOS may have a significant impact on this patients health and reduce the rate of mortality and morbidity.
News: Improved conditions by Alpha-Lipoic Acid (ALA)
Results of the article “Alpha-Lipoic Acid may improve the clinical, endocrine and metabolic features of polycystic ovary syndrome through an insulin-sensitizing effect and an antioxidant action”, published in Reproductive Sciences, 26 : 373A-374A, (2019) by Tropea, Anna et al. showed a significant increase of the number of spontaneous cycles after six months of treatment.
A significant reduction of HOMA index was found as well as basal serum level of insulin and significant increase of SHBG level. And they observed a decrease of oxidative stress markers (MDA) with an increase of Coenzyme Q10.
They concluded that their study shows ALA treatment ability to improve clinical and metabolic features in patients with PCOS, increasing insulin sensitivity and reducing oxidative stress. And they concluded that this result strenghthens the hypothesized link between insulin resistance/ hyperinsulinemia and oxidative damage and lead to new therapeutic strategies in patients with PCOS.